Benzone
Brand names,
Benzone
Analogs
Benzone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Benzone
Chemical_Formula
C19H20N2O2
Benzone
RX_link
No information avaliable
Benzone
fda sheet
Benzone
msds (material safety sheet)
Benzone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Benzone
Molecular Weight
308.374 g/mol
Benzone
Melting Point
105 oC
Benzone
H2O Solubility
47.5 mg/L
Benzone
State
Solid
Benzone
LogP
4.214
Benzone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Benzone
Indication
For the treatment of backache and ankylosing spondylitis
Benzone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Benzone
Absorption
No information avaliable
Benzone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Benzone
Patient Information
No information avaliable
Benzone
Organisms Affected
Humans and other mammals