Praecirheumin
Brand names,
Praecirheumin
Analogs
Praecirheumin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Praecirheumin
Chemical_Formula
C19H20N2O2
Praecirheumin
RX_link
No information avaliable
Praecirheumin
fda sheet
Praecirheumin
msds (material safety sheet)
Praecirheumin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Praecirheumin
Molecular Weight
308.374 g/mol
Praecirheumin
Melting Point
105 oC
Praecirheumin
H2O Solubility
47.5 mg/L
Praecirheumin
State
Solid
Praecirheumin
LogP
4.214
Praecirheumin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Praecirheumin
Indication
For the treatment of backache and ankylosing spondylitis
Praecirheumin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Praecirheumin
Absorption
No information avaliable
Praecirheumin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Praecirheumin
Patient Information
No information avaliable
Praecirheumin
Organisms Affected
Humans and other mammals