Alka Butazolidin
Brand names,
Alka Butazolidin
Analogs
Alka Butazolidin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Alka Butazolidin
Chemical_Formula
C19H20N2O2
Alka Butazolidin
RX_link
No information avaliable
Alka Butazolidin
fda sheet
Alka Butazolidin
msds (material safety sheet)
Alka Butazolidin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Alka Butazolidin
Molecular Weight
308.374 g/mol
Alka Butazolidin
Melting Point
105 oC
Alka Butazolidin
H2O Solubility
47.5 mg/L
Alka Butazolidin
State
Solid
Alka Butazolidin
LogP
4.214
Alka Butazolidin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Alka Butazolidin
Indication
For the treatment of backache and ankylosing spondylitis
Alka Butazolidin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Alka Butazolidin
Absorption
No information avaliable
Alka Butazolidin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Alka Butazolidin
Patient Information
No information avaliable
Alka Butazolidin
Organisms Affected
Humans and other mammals