Eributazone
Brand names,
Eributazone
Analogs
Eributazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Eributazone
Chemical_Formula
C19H20N2O2
Eributazone
RX_link
No information avaliable
Eributazone
fda sheet
Eributazone
msds (material safety sheet)
Eributazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Eributazone
Molecular Weight
308.374 g/mol
Eributazone
Melting Point
105 oC
Eributazone
H2O Solubility
47.5 mg/L
Eributazone
State
Solid
Eributazone
LogP
4.214
Eributazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Eributazone
Indication
For the treatment of backache and ankylosing spondylitis
Eributazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Eributazone
Absorption
No information avaliable
Eributazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Eributazone
Patient Information
No information avaliable
Eributazone
Organisms Affected
Humans and other mammals