Robizone
Brand names,
Robizone
Analogs
Robizone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Robizone
Chemical_Formula
C19H20N2O2
Robizone
RX_link
No information avaliable
Robizone
fda sheet
Robizone
msds (material safety sheet)
Robizone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Robizone
Molecular Weight
308.374 g/mol
Robizone
Melting Point
105 oC
Robizone
H2O Solubility
47.5 mg/L
Robizone
State
Solid
Robizone
LogP
4.214
Robizone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Robizone
Indication
For the treatment of backache and ankylosing spondylitis
Robizone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Robizone
Absorption
No information avaliable
Robizone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Robizone
Patient Information
No information avaliable
Robizone
Organisms Affected
Humans and other mammals