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Mephabutazon Brand names, Mephabutazon Analogs

Mephabutazon Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Mephabutazon Chemical_Formula


Mephabutazon RX_link

No information avaliable

Mephabutazon fda sheet

Mephabutazon msds (material safety sheet)

Mephabutazon MSDS

Mephabutazon Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Mephabutazon Molecular Weight

308.374 g/mol

Mephabutazon Melting Point

105 oC

Mephabutazon H2O Solubility

47.5 mg/L

Mephabutazon State


Mephabutazon LogP


Mephabutazon Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Mephabutazon Indication

For the treatment of backache and ankylosing spondylitis

Mephabutazon Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Mephabutazon Absorption

No information avaliable

Mephabutazon side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Mephabutazon Patient Information

No information avaliable

Mephabutazon Organisms Affected

Humans and other mammals