Mephabutazon
Brand names,
Mephabutazon
Analogs
Mephabutazon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Mephabutazon
Chemical_Formula
C19H20N2O2
Mephabutazon
RX_link
No information avaliable
Mephabutazon
fda sheet
Mephabutazon
msds (material safety sheet)
Mephabutazon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Mephabutazon
Molecular Weight
308.374 g/mol
Mephabutazon
Melting Point
105 oC
Mephabutazon
H2O Solubility
47.5 mg/L
Mephabutazon
State
Solid
Mephabutazon
LogP
4.214
Mephabutazon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Mephabutazon
Indication
For the treatment of backache and ankylosing spondylitis
Mephabutazon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Mephabutazon
Absorption
No information avaliable
Mephabutazon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Mephabutazon
Patient Information
No information avaliable
Mephabutazon
Organisms Affected
Humans and other mammals