Chembutazone
Brand names,
Chembutazone
Analogs
Chembutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Chembutazone
Chemical_Formula
C19H20N2O2
Chembutazone
RX_link
No information avaliable
Chembutazone
fda sheet
Chembutazone
msds (material safety sheet)
Chembutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Chembutazone
Molecular Weight
308.374 g/mol
Chembutazone
Melting Point
105 oC
Chembutazone
H2O Solubility
47.5 mg/L
Chembutazone
State
Solid
Chembutazone
LogP
4.214
Chembutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Chembutazone
Indication
For the treatment of backache and ankylosing spondylitis
Chembutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Chembutazone
Absorption
No information avaliable
Chembutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Chembutazone
Patient Information
No information avaliable
Chembutazone
Organisms Affected
Humans and other mammals