Alqoverin
Brand names,
Alqoverin
Analogs
Alqoverin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Alqoverin
Chemical_Formula
C19H20N2O2
Alqoverin
RX_link
No information avaliable
Alqoverin
fda sheet
Alqoverin
msds (material safety sheet)
Alqoverin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Alqoverin
Molecular Weight
308.374 g/mol
Alqoverin
Melting Point
105 oC
Alqoverin
H2O Solubility
47.5 mg/L
Alqoverin
State
Solid
Alqoverin
LogP
4.214
Alqoverin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Alqoverin
Indication
For the treatment of backache and ankylosing spondylitis
Alqoverin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Alqoverin
Absorption
No information avaliable
Alqoverin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Alqoverin
Patient Information
No information avaliable
Alqoverin
Organisms Affected
Humans and other mammals