Fenibutazona
Brand names,
Fenibutazona
Analogs
Fenibutazona
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenibutazona
Chemical_Formula
C19H20N2O2
Fenibutazona
RX_link
No information avaliable
Fenibutazona
fda sheet
Fenibutazona
msds (material safety sheet)
Fenibutazona
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenibutazona
Molecular Weight
308.374 g/mol
Fenibutazona
Melting Point
105 oC
Fenibutazona
H2O Solubility
47.5 mg/L
Fenibutazona
State
Solid
Fenibutazona
LogP
4.214
Fenibutazona
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenibutazona
Indication
For the treatment of backache and ankylosing spondylitis
Fenibutazona
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenibutazona
Absorption
No information avaliable
Fenibutazona
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenibutazona
Patient Information
No information avaliable
Fenibutazona
Organisms Affected
Humans and other mammals