Butiwas-Simple
Brand names,
Butiwas-Simple
Analogs
Butiwas-Simple
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butiwas-Simple
Chemical_Formula
C19H20N2O2
Butiwas-Simple
RX_link
No information avaliable
Butiwas-Simple
fda sheet
Butiwas-Simple
msds (material safety sheet)
Butiwas-Simple
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butiwas-Simple
Molecular Weight
308.374 g/mol
Butiwas-Simple
Melting Point
105 oC
Butiwas-Simple
H2O Solubility
47.5 mg/L
Butiwas-Simple
State
Solid
Butiwas-Simple
LogP
4.214
Butiwas-Simple
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butiwas-Simple
Indication
For the treatment of backache and ankylosing spondylitis
Butiwas-Simple
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butiwas-Simple
Absorption
No information avaliable
Butiwas-Simple
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butiwas-Simple
Patient Information
No information avaliable
Butiwas-Simple
Organisms Affected
Humans and other mammals