Intalbut
Brand names,
Intalbut
Analogs
Intalbut
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Intalbut
Chemical_Formula
C19H20N2O2
Intalbut
RX_link
No information avaliable
Intalbut
fda sheet
Intalbut
msds (material safety sheet)
Intalbut
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Intalbut
Molecular Weight
308.374 g/mol
Intalbut
Melting Point
105 oC
Intalbut
H2O Solubility
47.5 mg/L
Intalbut
State
Solid
Intalbut
LogP
4.214
Intalbut
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Intalbut
Indication
For the treatment of backache and ankylosing spondylitis
Intalbut
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Intalbut
Absorption
No information avaliable
Intalbut
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Intalbut
Patient Information
No information avaliable
Intalbut
Organisms Affected
Humans and other mammals