Butadione
Brand names,
Butadione
Analogs
Butadione
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butadione
Chemical_Formula
C19H20N2O2
Butadione
RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
Butadione
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butadione
Molecular Weight
308.374 g/mol
Butadione
Melting Point
105 oC
Butadione
H2O Solubility
47.5 mg/L
Butadione
State
Solid
Butadione
LogP
4.214
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Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butadione
Indication
For the treatment of backache and ankylosing spondylitis
Butadione
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butadione
Absorption
No information avaliable
Butadione
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butadione
Patient Information
No information avaliable
Butadione
Organisms Affected
Humans and other mammals