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Butadione Brand names, Butadione Analogs

Butadione Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Butadione Chemical_Formula


Butadione RX_link

No information avaliable

Butadione fda sheet

Butadione msds (material safety sheet)

Butadione MSDS

Butadione Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Butadione Molecular Weight

308.374 g/mol

Butadione Melting Point

105 oC

Butadione H2O Solubility

47.5 mg/L

Butadione State


Butadione LogP


Butadione Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Butadione Indication

For the treatment of backache and ankylosing spondylitis

Butadione Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Butadione Absorption

No information avaliable

Butadione side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Butadione Patient Information

No information avaliable

Butadione Organisms Affected

Humans and other mammals