Butylpyrin
Brand names,
Butylpyrin
Analogs
Butylpyrin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butylpyrin
Chemical_Formula
C19H20N2O2
Butylpyrin
RX_link
No information avaliable
Butylpyrin
fda sheet
Butylpyrin
msds (material safety sheet)
Butylpyrin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butylpyrin
Molecular Weight
308.374 g/mol
Butylpyrin
Melting Point
105 oC
Butylpyrin
H2O Solubility
47.5 mg/L
Butylpyrin
State
Solid
Butylpyrin
LogP
4.214
Butylpyrin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butylpyrin
Indication
For the treatment of backache and ankylosing spondylitis
Butylpyrin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butylpyrin
Absorption
No information avaliable
Butylpyrin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butylpyrin
Patient Information
No information avaliable
Butylpyrin
Organisms Affected
Humans and other mammals