Todalgil
Brand names,
Todalgil
Analogs
Todalgil
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Todalgil
Chemical_Formula
C19H20N2O2
Todalgil
RX_link
No information avaliable
Todalgil
fda sheet
Todalgil
msds (material safety sheet)
Todalgil
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Todalgil
Molecular Weight
308.374 g/mol
Todalgil
Melting Point
105 oC
Todalgil
H2O Solubility
47.5 mg/L
Todalgil
State
Solid
Todalgil
LogP
4.214
Todalgil
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Todalgil
Indication
For the treatment of backache and ankylosing spondylitis
Todalgil
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Todalgil
Absorption
No information avaliable
Todalgil
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Todalgil
Patient Information
No information avaliable
Todalgil
Organisms Affected
Humans and other mammals