Apo-Phenylbutazone
Brand names,
Apo-Phenylbutazone
Analogs
Apo-Phenylbutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Apo-Phenylbutazone
Chemical_Formula
C19H20N2O2
Apo-Phenylbutazone
RX_link
No information avaliable
Apo-Phenylbutazone
fda sheet
Apo-Phenylbutazone
msds (material safety sheet)
Apo-Phenylbutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Apo-Phenylbutazone
Molecular Weight
308.374 g/mol
Apo-Phenylbutazone
Melting Point
105 oC
Apo-Phenylbutazone
H2O Solubility
47.5 mg/L
Apo-Phenylbutazone
State
Solid
Apo-Phenylbutazone
LogP
4.214
Apo-Phenylbutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Apo-Phenylbutazone
Indication
For the treatment of backache and ankylosing spondylitis
Apo-Phenylbutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Apo-Phenylbutazone
Absorption
No information avaliable
Apo-Phenylbutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Apo-Phenylbutazone
Patient Information
No information avaliable
Apo-Phenylbutazone
Organisms Affected
Humans and other mammals