Intrabutazone
Brand names,
Intrabutazone
Analogs
Intrabutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Intrabutazone
Chemical_Formula
C19H20N2O2
Intrabutazone
RX_link
No information avaliable
Intrabutazone
fda sheet
Intrabutazone
msds (material safety sheet)
Intrabutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Intrabutazone
Molecular Weight
308.374 g/mol
Intrabutazone
Melting Point
105 oC
Intrabutazone
H2O Solubility
47.5 mg/L
Intrabutazone
State
Solid
Intrabutazone
LogP
4.214
Intrabutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Intrabutazone
Indication
For the treatment of backache and ankylosing spondylitis
Intrabutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Intrabutazone
Absorption
No information avaliable
Intrabutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Intrabutazone
Patient Information
No information avaliable
Intrabutazone
Organisms Affected
Humans and other mammals