Rubatone
Brand names,
Rubatone
Analogs
Rubatone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Rubatone
Chemical_Formula
C19H20N2O2
Rubatone
RX_link
No information avaliable
Rubatone
fda sheet
Rubatone
msds (material safety sheet)
Rubatone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Rubatone
Molecular Weight
308.374 g/mol
Rubatone
Melting Point
105 oC
Rubatone
H2O Solubility
47.5 mg/L
Rubatone
State
Solid
Rubatone
LogP
4.214
Rubatone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Rubatone
Indication
For the treatment of backache and ankylosing spondylitis
Rubatone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Rubatone
Absorption
No information avaliable
Rubatone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Rubatone
Patient Information
No information avaliable
Rubatone
Organisms Affected
Humans and other mammals