Butartrina
Brand names,
Butartrina
Analogs
Butartrina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butartrina
Chemical_Formula
C19H20N2O2
Butartrina
RX_link
No information avaliable
Butartrina
fda sheet
Butartrina
msds (material safety sheet)
Butartrina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butartrina
Molecular Weight
308.374 g/mol
Butartrina
Melting Point
105 oC
Butartrina
H2O Solubility
47.5 mg/L
Butartrina
State
Solid
Butartrina
LogP
4.214
Butartrina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butartrina
Indication
For the treatment of backache and ankylosing spondylitis
Butartrina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butartrina
Absorption
No information avaliable
Butartrina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butartrina
Patient Information
No information avaliable
Butartrina
Organisms Affected
Humans and other mammals