Usaf Ge-15
Brand names,
Usaf Ge-15
Analogs
Usaf Ge-15
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Usaf Ge-15
Chemical_Formula
C19H20N2O2
Usaf Ge-15
RX_link
No information avaliable
Usaf Ge-15
fda sheet
Usaf Ge-15
msds (material safety sheet)
Usaf Ge-15
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Usaf Ge-15
Molecular Weight
308.374 g/mol
Usaf Ge-15
Melting Point
105 oC
Usaf Ge-15
H2O Solubility
47.5 mg/L
Usaf Ge-15
State
Solid
Usaf Ge-15
LogP
4.214
Usaf Ge-15
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Usaf Ge-15
Indication
For the treatment of backache and ankylosing spondylitis
Usaf Ge-15
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Usaf Ge-15
Absorption
No information avaliable
Usaf Ge-15
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Usaf Ge-15
Patient Information
No information avaliable
Usaf Ge-15
Organisms Affected
Humans and other mammals