Fenilidina
Brand names,
Fenilidina
Analogs
Fenilidina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenilidina
Chemical_Formula
C19H20N2O2
Fenilidina
RX_link
No information avaliable
Fenilidina
fda sheet
Fenilidina
msds (material safety sheet)
Fenilidina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenilidina
Molecular Weight
308.374 g/mol
Fenilidina
Melting Point
105 oC
Fenilidina
H2O Solubility
47.5 mg/L
Fenilidina
State
Solid
Fenilidina
LogP
4.214
Fenilidina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenilidina
Indication
For the treatment of backache and ankylosing spondylitis
Fenilidina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenilidina
Absorption
No information avaliable
Fenilidina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenilidina
Patient Information
No information avaliable
Fenilidina
Organisms Affected
Humans and other mammals