Butartril
Brand names,
Butartril
Analogs
Butartril
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butartril
Chemical_Formula
C19H20N2O2
Butartril
RX_link
No information avaliable
Butartril
fda sheet
Butartril
msds (material safety sheet)
Butartril
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butartril
Molecular Weight
308.374 g/mol
Butartril
Melting Point
105 oC
Butartril
H2O Solubility
47.5 mg/L
Butartril
State
Solid
Butartril
LogP
4.214
Butartril
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butartril
Indication
For the treatment of backache and ankylosing spondylitis
Butartril
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butartril
Absorption
No information avaliable
Butartril
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butartril
Patient Information
No information avaliable
Butartril
Organisms Affected
Humans and other mammals