Butazona
Brand names,
Butazona
Analogs
Butazona
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butazona
Chemical_Formula
C19H20N2O2
Butazona
RX_link
No information avaliable
Butazona
fda sheet
Butazona
msds (material safety sheet)
Butazona
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butazona
Molecular Weight
308.374 g/mol
Butazona
Melting Point
105 oC
Butazona
H2O Solubility
47.5 mg/L
Butazona
State
Solid
Butazona
LogP
4.214
Butazona
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butazona
Indication
For the treatment of backache and ankylosing spondylitis
Butazona
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butazona
Absorption
No information avaliable
Butazona
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butazona
Patient Information
No information avaliable
Butazona
Organisms Affected
Humans and other mammals