Cotylbutazone
Brand names,
Cotylbutazone
Analogs
Cotylbutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Cotylbutazone
Chemical_Formula
C19H20N2O2
Cotylbutazone
RX_link
No information avaliable
Cotylbutazone
fda sheet
Cotylbutazone
msds (material safety sheet)
Cotylbutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Cotylbutazone
Molecular Weight
308.374 g/mol
Cotylbutazone
Melting Point
105 oC
Cotylbutazone
H2O Solubility
47.5 mg/L
Cotylbutazone
State
Solid
Cotylbutazone
LogP
4.214
Cotylbutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Cotylbutazone
Indication
For the treatment of backache and ankylosing spondylitis
Cotylbutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Cotylbutazone
Absorption
No information avaliable
Cotylbutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Cotylbutazone
Patient Information
No information avaliable
Cotylbutazone
Organisms Affected
Humans and other mammals