Phenyzene
Brand names,
Phenyzene
Analogs
Phenyzene
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Phenyzene
Chemical_Formula
C19H20N2O2
Phenyzene
RX_link
No information avaliable
Phenyzene
fda sheet
Phenyzene
msds (material safety sheet)
Phenyzene
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Phenyzene
Molecular Weight
308.374 g/mol
Phenyzene
Melting Point
105 oC
Phenyzene
H2O Solubility
47.5 mg/L
Phenyzene
State
Solid
Phenyzene
LogP
4.214
Phenyzene
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Phenyzene
Indication
For the treatment of backache and ankylosing spondylitis
Phenyzene
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Phenyzene
Absorption
No information avaliable
Phenyzene
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Phenyzene
Patient Information
No information avaliable
Phenyzene
Organisms Affected
Humans and other mammals