Arthrizon
Brand names,
Arthrizon
Analogs
Arthrizon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Arthrizon
Chemical_Formula
C19H20N2O2
Arthrizon
RX_link
No information avaliable
Arthrizon
fda sheet
Arthrizon
msds (material safety sheet)
Arthrizon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Arthrizon
Molecular Weight
308.374 g/mol
Arthrizon
Melting Point
105 oC
Arthrizon
H2O Solubility
47.5 mg/L
Arthrizon
State
Solid
Arthrizon
LogP
4.214
Arthrizon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Arthrizon
Indication
For the treatment of backache and ankylosing spondylitis
Arthrizon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Arthrizon
Absorption
No information avaliable
Arthrizon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Arthrizon
Patient Information
No information avaliable
Arthrizon
Organisms Affected
Humans and other mammals