Diphenylbutazone
Brand names,
Diphenylbutazone
Analogs
Diphenylbutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Diphenylbutazone
Chemical_Formula
C19H20N2O2
Diphenylbutazone
RX_link
No information avaliable
Diphenylbutazone
fda sheet
Diphenylbutazone
msds (material safety sheet)
Diphenylbutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Diphenylbutazone
Molecular Weight
308.374 g/mol
Diphenylbutazone
Melting Point
105 oC
Diphenylbutazone
H2O Solubility
47.5 mg/L
Diphenylbutazone
State
Solid
Diphenylbutazone
LogP
4.214
Diphenylbutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Diphenylbutazone
Indication
For the treatment of backache and ankylosing spondylitis
Diphenylbutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Diphenylbutazone
Absorption
No information avaliable
Diphenylbutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Diphenylbutazone
Patient Information
No information avaliable
Diphenylbutazone
Organisms Affected
Humans and other mammals