Elmedal
Brand names,
Elmedal
Analogs
Elmedal
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Elmedal
Chemical_Formula
C19H20N2O2
Elmedal
RX_link
No information avaliable
Elmedal
fda sheet
Elmedal
msds (material safety sheet)
Elmedal
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Elmedal
Molecular Weight
308.374 g/mol
Elmedal
Melting Point
105 oC
Elmedal
H2O Solubility
47.5 mg/L
Elmedal
State
Solid
Elmedal
LogP
4.214
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Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Elmedal
Indication
For the treatment of backache and ankylosing spondylitis
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Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Elmedal
Absorption
No information avaliable
Elmedal
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Elmedal
Patient Information
No information avaliable
Elmedal
Organisms Affected
Humans and other mammals