Buzon
Brand names,
Buzon
Analogs
Buzon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Buzon
Chemical_Formula
C19H20N2O2
Buzon
RX_link
No information avaliable
Buzon
fda sheet
Buzon
msds (material safety sheet)
Buzon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Buzon
Molecular Weight
308.374 g/mol
Buzon
Melting Point
105 oC
Buzon
H2O Solubility
47.5 mg/L
Buzon
State
Solid
Buzon
LogP
4.214
Buzon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Buzon
Indication
For the treatment of backache and ankylosing spondylitis
Buzon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Buzon
Absorption
No information avaliable
Buzon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Buzon
Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals