Butazina
Brand names,
Butazina
Analogs
Butazina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butazina
Chemical_Formula
C19H20N2O2
Butazina
RX_link
No information avaliable
Butazina
fda sheet
Butazina
msds (material safety sheet)
Butazina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butazina
Molecular Weight
308.374 g/mol
Butazina
Melting Point
105 oC
Butazina
H2O Solubility
47.5 mg/L
Butazina
State
Solid
Butazina
LogP
4.214
Butazina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butazina
Indication
For the treatment of backache and ankylosing spondylitis
Butazina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butazina
Absorption
No information avaliable
Butazina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butazina
Patient Information
No information avaliable
Butazina
Organisms Affected
Humans and other mammals