Butazolidine
Brand names,
Butazolidine
Analogs
Butazolidine
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butazolidine
Chemical_Formula
C19H20N2O2
Butazolidine
RX_link
No information avaliable
Butazolidine
fda sheet
Butazolidine
msds (material safety sheet)
Butazolidine
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butazolidine
Molecular Weight
308.374 g/mol
Butazolidine
Melting Point
105 oC
Butazolidine
H2O Solubility
47.5 mg/L
Butazolidine
State
Solid
Butazolidine
LogP
4.214
Butazolidine
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butazolidine
Indication
For the treatment of backache and ankylosing spondylitis
Butazolidine
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butazolidine
Absorption
No information avaliable
Butazolidine
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butazolidine
Patient Information
No information avaliable
Butazolidine
Organisms Affected
Humans and other mammals