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Therazone Brand names, Therazone Analogs

Therazone Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Therazone Chemical_Formula


Therazone RX_link

No information avaliable

Therazone fda sheet

Therazone msds (material safety sheet)

Therazone MSDS

Therazone Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Therazone Molecular Weight

308.374 g/mol

Therazone Melting Point

105 oC

Therazone H2O Solubility

47.5 mg/L

Therazone State


Therazone LogP


Therazone Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Therazone Indication

For the treatment of backache and ankylosing spondylitis

Therazone Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Therazone Absorption

No information avaliable

Therazone side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Therazone Patient Information

No information avaliable

Therazone Organisms Affected

Humans and other mammals