Anpuzone
Brand names,
Anpuzone
Analogs
Anpuzone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Anpuzone
Chemical_Formula
C19H20N2O2
Anpuzone
RX_link
No information avaliable
Anpuzone
fda sheet
Anpuzone
msds (material safety sheet)
Anpuzone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Anpuzone
Molecular Weight
308.374 g/mol
Anpuzone
Melting Point
105 oC
Anpuzone
H2O Solubility
47.5 mg/L
Anpuzone
State
Solid
Anpuzone
LogP
4.214
Anpuzone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Anpuzone
Indication
For the treatment of backache and ankylosing spondylitis
Anpuzone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Anpuzone
Absorption
No information avaliable
Anpuzone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Anpuzone
Patient Information
No information avaliable
Anpuzone
Organisms Affected
Humans and other mammals