Fenilbutina
Brand names,
Fenilbutina
Analogs
Fenilbutina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenilbutina
Chemical_Formula
C19H20N2O2
Fenilbutina
RX_link
No information avaliable
Fenilbutina
fda sheet
Fenilbutina
msds (material safety sheet)
Fenilbutina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenilbutina
Molecular Weight
308.374 g/mol
Fenilbutina
Melting Point
105 oC
Fenilbutina
H2O Solubility
47.5 mg/L
Fenilbutina
State
Solid
Fenilbutina
LogP
4.214
Fenilbutina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenilbutina
Indication
For the treatment of backache and ankylosing spondylitis
Fenilbutina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenilbutina
Absorption
No information avaliable
Fenilbutina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenilbutina
Patient Information
No information avaliable
Fenilbutina
Organisms Affected
Humans and other mammals