Butalidon
Brand names,
Butalidon
Analogs
Butalidon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butalidon
Chemical_Formula
C19H20N2O2
Butalidon
RX_link
No information avaliable
Butalidon
fda sheet
Butalidon
msds (material safety sheet)
Butalidon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butalidon
Molecular Weight
308.374 g/mol
Butalidon
Melting Point
105 oC
Butalidon
H2O Solubility
47.5 mg/L
Butalidon
State
Solid
Butalidon
LogP
4.214
Butalidon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butalidon
Indication
For the treatment of backache and ankylosing spondylitis
Butalidon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butalidon
Absorption
No information avaliable
Butalidon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butalidon
Patient Information
No information avaliable
Butalidon
Organisms Affected
Humans and other mammals