Butazolidin
Brand names,
Butazolidin
Analogs
Butazolidin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butazolidin
Chemical_Formula
C19H20N2O2
Butazolidin
RX_link
No information avaliable
Butazolidin
fda sheet
Butazolidin
msds (material safety sheet)
Butazolidin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butazolidin
Molecular Weight
308.374 g/mol
Butazolidin
Melting Point
105 oC
Butazolidin
H2O Solubility
47.5 mg/L
Butazolidin
State
Solid
Butazolidin
LogP
4.214
Butazolidin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butazolidin
Indication
For the treatment of backache and ankylosing spondylitis
Butazolidin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butazolidin
Absorption
No information avaliable
Butazolidin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butazolidin
Patient Information
No information avaliable
Butazolidin
Organisms Affected
Humans and other mammals