Fenibutal
Brand names,
Fenibutal
Analogs
Fenibutal
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenibutal
Chemical_Formula
C19H20N2O2
Fenibutal
RX_link
No information avaliable
Fenibutal
fda sheet
Fenibutal
msds (material safety sheet)
Fenibutal
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenibutal
Molecular Weight
308.374 g/mol
Fenibutal
Melting Point
105 oC
Fenibutal
H2O Solubility
47.5 mg/L
Fenibutal
State
Solid
Fenibutal
LogP
4.214
Fenibutal
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenibutal
Indication
For the treatment of backache and ankylosing spondylitis
Fenibutal
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenibutal
Absorption
No information avaliable
Fenibutal
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenibutal
Patient Information
No information avaliable
Fenibutal
Organisms Affected
Humans and other mammals