Equipalazone
Brand names,
Equipalazone
Analogs
Equipalazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Equipalazone
Chemical_Formula
C19H20N2O2
Equipalazone
RX_link
No information avaliable
Equipalazone
fda sheet
Equipalazone
msds (material safety sheet)
Equipalazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Equipalazone
Molecular Weight
308.374 g/mol
Equipalazone
Melting Point
105 oC
Equipalazone
H2O Solubility
47.5 mg/L
Equipalazone
State
Solid
Equipalazone
LogP
4.214
Equipalazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Equipalazone
Indication
For the treatment of backache and ankylosing spondylitis
Equipalazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Equipalazone
Absorption
No information avaliable
Equipalazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Equipalazone
Patient Information
No information avaliable
Equipalazone
Organisms Affected
Humans and other mammals