Phenyl-Mobuzon
Brand names,
Phenyl-Mobuzon
Analogs
Phenyl-Mobuzon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Phenyl-Mobuzon
Chemical_Formula
C19H20N2O2
Phenyl-Mobuzon
RX_link
No information avaliable
Phenyl-Mobuzon
fda sheet
Phenyl-Mobuzon
msds (material safety sheet)
Phenyl-Mobuzon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Phenyl-Mobuzon
Molecular Weight
308.374 g/mol
Phenyl-Mobuzon
Melting Point
105 oC
Phenyl-Mobuzon
H2O Solubility
47.5 mg/L
Phenyl-Mobuzon
State
Solid
Phenyl-Mobuzon
LogP
4.214
Phenyl-Mobuzon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Phenyl-Mobuzon
Indication
For the treatment of backache and ankylosing spondylitis
Phenyl-Mobuzon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Phenyl-Mobuzon
Absorption
No information avaliable
Phenyl-Mobuzon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Phenyl-Mobuzon
Patient Information
No information avaliable
Phenyl-Mobuzon
Organisms Affected
Humans and other mammals