Fenotone
Brand names,
Fenotone
Analogs
Fenotone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenotone
Chemical_Formula
C19H20N2O2
Fenotone
RX_link
No information avaliable
Fenotone
fda sheet
Fenotone
msds (material safety sheet)
Fenotone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenotone
Molecular Weight
308.374 g/mol
Fenotone
Melting Point
105 oC
Fenotone
H2O Solubility
47.5 mg/L
Fenotone
State
Solid
Fenotone
LogP
4.214
Fenotone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenotone
Indication
For the treatment of backache and ankylosing spondylitis
Fenotone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenotone
Absorption
No information avaliable
Fenotone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenotone
Patient Information
No information avaliable
Fenotone
Organisms Affected
Humans and other mammals