Kadol
Brand names,
Kadol
Analogs
Kadol
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Kadol
Chemical_Formula
C19H20N2O2
Kadol
RX_link
No information avaliable
Kadol
fda sheet
Kadol
msds (material safety sheet)
Kadol
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Kadol
Molecular Weight
308.374 g/mol
Kadol
Melting Point
105 oC
Kadol
H2O Solubility
47.5 mg/L
Kadol
State
Solid
Kadol
LogP
4.214
Kadol
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Kadol
Indication
For the treatment of backache and ankylosing spondylitis
Kadol
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Kadol
Absorption
No information avaliable
Kadol
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Kadol
Patient Information
No information avaliable
Kadol
Organisms Affected
Humans and other mammals