Digibutina
Brand names,
Digibutina
Analogs
Digibutina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Digibutina
Chemical_Formula
C19H20N2O2
Digibutina
RX_link
No information avaliable
Digibutina
fda sheet
Digibutina
msds (material safety sheet)
Digibutina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Digibutina
Molecular Weight
308.374 g/mol
Digibutina
Melting Point
105 oC
Digibutina
H2O Solubility
47.5 mg/L
Digibutina
State
Solid
Digibutina
LogP
4.214
Digibutina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Digibutina
Indication
For the treatment of backache and ankylosing spondylitis
Digibutina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Digibutina
Absorption
No information avaliable
Digibutina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Digibutina
Patient Information
No information avaliable
Digibutina
Organisms Affected
Humans and other mammals