Zolidinum
Brand names,
Zolidinum
Analogs
Zolidinum
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Zolidinum
Chemical_Formula
C19H20N2O2
Zolidinum
RX_link
No information avaliable
Zolidinum
fda sheet
Zolidinum
msds (material safety sheet)
Zolidinum
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Zolidinum
Molecular Weight
308.374 g/mol
Zolidinum
Melting Point
105 oC
Zolidinum
H2O Solubility
47.5 mg/L
Zolidinum
State
Solid
Zolidinum
LogP
4.214
Zolidinum
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Zolidinum
Indication
For the treatment of backache and ankylosing spondylitis
Zolidinum
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Zolidinum
Absorption
No information avaliable
Zolidinum
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Zolidinum
Patient Information
No information avaliable
Zolidinum
Organisms Affected
Humans and other mammals