Pyrazolidin
Brand names,
Pyrazolidin
Analogs
Pyrazolidin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Pyrazolidin
Chemical_Formula
C19H20N2O2
Pyrazolidin
RX_link
No information avaliable
Pyrazolidin
fda sheet
Pyrazolidin
msds (material safety sheet)
Pyrazolidin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Pyrazolidin
Molecular Weight
308.374 g/mol
Pyrazolidin
Melting Point
105 oC
Pyrazolidin
H2O Solubility
47.5 mg/L
Pyrazolidin
State
Solid
Pyrazolidin
LogP
4.214
Pyrazolidin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Pyrazolidin
Indication
For the treatment of backache and ankylosing spondylitis
Pyrazolidin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Pyrazolidin
Absorption
No information avaliable
Pyrazolidin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Pyrazolidin
Patient Information
No information avaliable
Pyrazolidin
Organisms Affected
Humans and other mammals