Phenyzone
Brand names,
Phenyzone
Analogs
Phenyzone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Phenyzone
Chemical_Formula
C19H20N2O2
Phenyzone
RX_link
No information avaliable
Phenyzone
fda sheet
Phenyzone
msds (material safety sheet)
Phenyzone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Phenyzone
Molecular Weight
308.374 g/mol
Phenyzone
Melting Point
105 oC
Phenyzone
H2O Solubility
47.5 mg/L
Phenyzone
State
Solid
Phenyzone
LogP
4.214
Phenyzone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Phenyzone
Indication
For the treatment of backache and ankylosing spondylitis
Phenyzone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Phenyzone
Absorption
No information avaliable
Phenyzone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Phenyzone
Patient Information
No information avaliable
Phenyzone
Organisms Affected
Humans and other mammals