Nadazone
Brand names,
Nadazone
Analogs
Nadazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Nadazone
Chemical_Formula
C19H20N2O2
Nadazone
RX_link
No information avaliable
Nadazone
fda sheet
Nadazone
msds (material safety sheet)
Nadazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Nadazone
Molecular Weight
308.374 g/mol
Nadazone
Melting Point
105 oC
Nadazone
H2O Solubility
47.5 mg/L
Nadazone
State
Solid
Nadazone
LogP
4.214
Nadazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Nadazone
Indication
For the treatment of backache and ankylosing spondylitis
Nadazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Nadazone
Absorption
No information avaliable
Nadazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Nadazone
Patient Information
No information avaliable
Nadazone
Organisms Affected
Humans and other mammals