Antadol
Brand names,
Antadol
Analogs
Antadol
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Antadol
Chemical_Formula
C19H20N2O2
Antadol
RX_link
No information avaliable
Antadol
fda sheet
Antadol
msds (material safety sheet)
Antadol
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Antadol
Molecular Weight
308.374 g/mol
Antadol
Melting Point
105 oC
Antadol
H2O Solubility
47.5 mg/L
Antadol
State
Solid
Antadol
LogP
4.214
Antadol
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Antadol
Indication
For the treatment of backache and ankylosing spondylitis
Antadol
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Antadol
Absorption
No information avaliable
Antadol
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Antadol
Patient Information
No information avaliable
Antadol
Organisms Affected
Humans and other mammals