Alkabutazona
Brand names,
Alkabutazona
Analogs
Alkabutazona
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Alkabutazona
Chemical_Formula
C19H20N2O2
Alkabutazona
RX_link
No information avaliable
Alkabutazona
fda sheet
Alkabutazona
msds (material safety sheet)
Alkabutazona
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Alkabutazona
Molecular Weight
308.374 g/mol
Alkabutazona
Melting Point
105 oC
Alkabutazona
H2O Solubility
47.5 mg/L
Alkabutazona
State
Solid
Alkabutazona
LogP
4.214
Alkabutazona
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Alkabutazona
Indication
For the treatment of backache and ankylosing spondylitis
Alkabutazona
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Alkabutazona
Absorption
No information avaliable
Alkabutazona
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Alkabutazona
Patient Information
No information avaliable
Alkabutazona
Organisms Affected
Humans and other mammals