Butalgina
Brand names,
Butalgina
Analogs
Butalgina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butalgina
Chemical_Formula
C19H20N2O2
Butalgina
RX_link
No information avaliable
Butalgina
fda sheet
Butalgina
msds (material safety sheet)
Butalgina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butalgina
Molecular Weight
308.374 g/mol
Butalgina
Melting Point
105 oC
Butalgina
H2O Solubility
47.5 mg/L
Butalgina
State
Solid
Butalgina
LogP
4.214
Butalgina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butalgina
Indication
For the treatment of backache and ankylosing spondylitis
Butalgina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butalgina
Absorption
No information avaliable
Butalgina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butalgina
Patient Information
No information avaliable
Butalgina
Organisms Affected
Humans and other mammals