Butazone
Brand names,
Butazone
Analogs
Butazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butazone
Chemical_Formula
C19H20N2O2
Butazone
RX_link
No information avaliable
Butazone
fda sheet
Butazone
msds (material safety sheet)
Butazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butazone
Molecular Weight
308.374 g/mol
Butazone
Melting Point
105 oC
Butazone
H2O Solubility
47.5 mg/L
Butazone
State
Solid
Butazone
LogP
4.214
Butazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butazone
Indication
For the treatment of backache and ankylosing spondylitis
Butazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butazone
Absorption
No information avaliable
Butazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butazone
Patient Information
No information avaliable
Butazone
Organisms Affected
Humans and other mammals