Reumazol
Brand names,
Reumazol
Analogs
Reumazol
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Reumazol
Chemical_Formula
C19H20N2O2
Reumazol
RX_link
No information avaliable
Reumazol
fda sheet
Reumazol
msds (material safety sheet)
Reumazol
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Reumazol
Molecular Weight
308.374 g/mol
Reumazol
Melting Point
105 oC
Reumazol
H2O Solubility
47.5 mg/L
Reumazol
State
Solid
Reumazol
LogP
4.214
Reumazol
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Reumazol
Indication
For the treatment of backache and ankylosing spondylitis
Reumazol
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Reumazol
Absorption
No information avaliable
Reumazol
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Reumazol
Patient Information
No information avaliable
Reumazol
Organisms Affected
Humans and other mammals